Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration by Sudesh Kumar Yadav

Author:Sudesh Kumar Yadav
Language: eng
Format: epub
Publisher: Springer Singapore, Singapore

4.3.1 Passive Drug Loading/Encapsulation

Passive drug loading is the technique in which the drug is encapsulated simultaneously during the formation of liposome vesicles. In passive loading, any molecule irrespective of its shape, charge and molecular mass can be loaded into the aqueous part or in the hydrophobic layer of liposomes. The attraction and repulsion between phospholipids of bilayer and encapsulated drug can affect the loading magnitude as increase or decrease (Barenholz 1996). Passive drug loading can be again classified into three different methods viz., mechanical, solvent dispersion and detergent removal.

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